# Endoscopic Sleeve Gastroplasty

> Citation bundle for Endoscopic Sleeve Gastroplasty on The Treatment Registry.
> URL: https://thetreatmentregistry.com/procedures/endoscopic-sleeve-gastroplasty
> Bundle URL: https://thetreatmentregistry.com/api/citations/procedures/endoscopic-sleeve-gastroplasty

- Category: weight-loss

## Description

In medicine, endoscopic sleeve gastroplasty (ESG) is a minimally-invasive, non-surgical (incisionless), endoscopic weight loss procedure that is part of the field of endoscopic bariatric therapies. To perform ESG, a physician sutures a patient's stomach into a narrower, smaller tube-like configuration.

## Overview

Endoscopic sleeve gastroplasty (ESG) is a minimally invasive, non-surgical and incisionless endoscopic weight-loss procedure, and one of the endoscopic bariatric therapies. Rather than removing part of the stomach through incisions, a physician passes an endoscope through the mouth and places sutures that draw the stomach into a narrower, smaller, tube-like configuration. The result is a more restricted stomach that leads patients to feel fuller sooner and eat fewer calories, which facilitates weight loss. Endoscopic bariatric therapies are judged mainly on total body weight loss and excess weight loss. In 2015 a joint expert panel from the American Society for Gastrointestinal Endoscopy and the American Society for Metabolic and Bariatric Surgery recommended that any new endoscopic weight-loss therapy should achieve excess weight loss above 25% with a serious adverse-event rate below 5%, and multiple studies indicate that ESG meets these thresholds. The MERIT study, the first and only randomised controlled trial of ESG for obesity, enrolled 209 adults with class I and II obesity (body mass index 30 to 40) across nine centres in the United States. Participants in the ESG arm lost 13.6% of body weight and 49.2% of excess body weight at one year, compared with 0.8% total body weight loss in the control arm, which received lifestyle modification only.

## FAQs

### What is endoscopic sleeve gastroplasty?

It is a minimally invasive, non-surgical and incisionless endoscopic weight-loss procedure that is part of the field of endoscopic bariatric therapies. A physician sutures the stomach into a narrower, smaller, tube-like configuration.

### Does ESG involve incisions or removing part of the stomach?

No. ESG is non-surgical and incisionless. The stomach is reshaped from the inside using sutures placed through an endoscope, rather than through external incisions.

### How does ESG cause weight loss?

By suturing the stomach into a narrower, more restricted shape, the procedure forces patients to feel fuller sooner and eat fewer calories, which facilitates weight loss.

### Who is ESG studied in?

The MERIT randomised controlled trial enrolled 209 adults with class I and II obesity, defined as a body mass index between 30 and 40, across nine centres in the United States.

### How much weight loss does it produce?

In the MERIT study, participants in the ESG arm lost 13.6% of body weight and 49.2% of excess body weight at one year, compared with 0.8% total body weight loss in the control arm, which received lifestyle modification only.

### What safety and effectiveness threshold applies to endoscopic weight-loss therapies?

In 2015 a joint expert panel from the American Society for Gastrointestinal Endoscopy and the American Society for Metabolic and Bariatric Surgery recommended that any new endoscopic weight-loss therapy achieve excess weight loss above 25% with a serious adverse-event rate below 5%. Multiple studies indicate that ESG satisfies these criteria.