# SADI-S

> Citation bundle for SADI-S on The Treatment Registry.
> URL: https://thetreatmentregistry.com/procedures/sadi-s
> Bundle URL: https://thetreatmentregistry.com/api/citations/procedures/sadi-s

- Category: weight-loss

## Description

Bariatric surgery is a group of surgical procedures used to manage obesity and related conditions. Long-term weight loss with bariatric surgery may be achieved through alteration of gut hormones, physical reduction of stomach size, reduction of nutrient absorption, or a combination of these.

## Overview

SADI-S (single anastomosis duodenal-ileal bypass with sleeve gastrectomy) is a variation on the duodenal switch (Wikipedia, CC BY-SA). Wikipedia says the surgeon makes a gastric sleeve, divides the duodenum and joins it to the intestine 250 to 300 cm from the ileocaecal valve (Wikipedia, CC BY-SA). SADI-S requires only a single anastomosis, compared with the duodenal switch (Wikipedia, CC BY-SA). SADI-S can be done laparoscopically or open (Wikipedia, CC BY-SA). The NHS names biliopancreatic diversion or duodenal bypass as less commonly used operations that can have more side effects than gastric bypass, and does not describe SADI-S (NHS, OGL v3.0). The NHS says weight loss surgery may be available at a BMI of 40 or more, or 35 to 40 with a condition that could improve with weight loss, with lower thresholds possible for some family backgrounds (NHS, OGL v3.0). Wikipedia says lifelong vitamin and mineral supplements are needed, with regular monitoring to prevent malnutrition (Wikipedia, CC BY-SA). Wikipedia also says gallstones, flatulence and diarrhoea are more frequent than in the non-bariatric population, and bile reflux is more likely than after a traditional duodenal switch (Wikipedia, CC BY-SA). ASMBS (2020) and IFSO (2018) have issued position statements on SADI-S (Wikipedia, CC BY-SA); the IFSO 2020 update says its 2018 statement noted insufficient long-term data.

## FAQs

### What is SADI-S?

SADI-S stands for single-anastomosis duodeno-ileal bypass with sleeve, a bariatric (weight-loss) operation. It combines a sleeve gastrectomy, which reduces the size of the stomach, with a single intestinal bypass that reroutes part of the small intestine. It is intended to support weight loss and improve obesity-related health conditions.

### How does SADI-S work?

It works in two ways: the sleeve reduces the stomach's capacity, and the intestinal bypass reduces the length of intestine that absorbs nutrients, which also affects gut hormones involved in hunger and fullness. It is a modification of the duodenal switch that uses a single intestinal connection rather than two. It is generally regarded as a more complex bariatric procedure.

### Who is a typical candidate?

Bariatric surgery is generally considered for people with obesity that has not responded to non-surgical measures, and eligibility is assessed against established medical criteria. Candidates usually undergo evaluation by a multidisciplinary team before surgery. A surgeon determines whether SADI-S is appropriate for the individual.

### What does recovery generally involve?

SADI-S is performed under general anaesthesia, commonly using keyhole (laparoscopic) techniques, and involves a hospital stay followed by a staged return to normal activity. Patients follow a structured diet that progresses from liquids to solid foods as they heal. Ongoing medical follow-up is an important part of recovery.

### What are the main risks?

As a major operation, recognised risks include bleeding, infection, blood clots, and leakage at surgical connections, along with the general risks of anaesthesia. Because it reduces nutrient absorption, it also carries a longer-term risk of nutritional and vitamin deficiencies. Lifelong nutritional monitoring and supplementation are generally required.

### Are the results permanent, and what does it cost?

SADI-S produces lasting anatomical changes, but long-term results depend on sustained changes to diet and lifestyle and on ongoing medical follow-up. Weight regain is possible if recommended habits are not maintained. Cost varies by clinic and country; see the destinations listed for this procedure.